Zhang, J., Luan, Q., Liu, Y., Lee, D. Y., and Wang, Z. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Fried, M. W., Navarro, V. J., Afdhal, N., Belle, S. H., Wahed, A. S., Hawke, R. L., Doo, E., Meyers, C. M., and Reddy, K. R. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Fried MW, Navarro VJ, Afdhal N, et al. 2022 Jan 11. doi: 10.1002/ptr.7364. Milk thistle can trigger allergic reactions. Other studies looking at milk thistle for cirrhosis have found conflicting results. Hepatology. Front Immunol. Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: a clinical trial study. View abstract. 5th ed. Med Sci Ress 1995;23:31-33. This compound is highly concentrated in the plants seeds. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Elsevier; 2021. https://www.clinicalkey.com. Early research shows that taking milk thistle by mouth might improve liver function and reduce risk of death. View abstract. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Theres conflicting research on the benefits of milk thistle for liver health. In:Drugs and Lactation Database (LactMed). 2010;154(3):239-244. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. 2019;69(11):630-638. This makes it very hard to establish a standard dose. Despite some anticancer effects observed in the laboratory, milk thistle supplementation has not been shown to alter the development or progression of cancer in human populations. 2007 Jun; 6(2):104-9. If your dog is consistently taking medication to manage another condition, then, . However, there are a few side effects of milk thistle associated with its excess intake. Taking milk thistle does not seem to improve either of these outcomes. Before taking milk thistle, talk to your healthcare provider if you are taking sirolimus. The effect of silymarin on liver enzymes in patients taking isotretinoin: a randomized clinical trial. Prog.Neuropsychopharmacol.Biol.Psychiatry 3-17-2010;34(2):362-365. Hikino, H., Kiso, Y., Wagner, H., and Fiebig, M. Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. View abstract. 2010;16(6):642-645. View abstract. Int.J Clin Pharmacol.Ther. Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: a randomized, double-blind, placebo-controlled trial. Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients. View abstract. The therapeutic potential of milk thistle in diabetes. Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, et al. It can be consumed in tea, tincture, extract, pill or powder form, making it easy to incorporate into your daily diet. Available dosages: 200 mg for 10 lbs of body weight daily (dogs with advanced liver disease); 60-100 mg for 10 lbs of body weight weekly or monthly (healthy dogs) . Kiesewetter, E., Leodolter, I., and Thaler, H. [Results of two double-blind studies on the effect of silymarine in chronic hepatitis (author's transl)]. Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Foods high in salt (sodium), such as some canned foods, processed meats (e.g., lunch meats, sausages, hot dogs, ham), and frozen dinners should be avoided. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. The effect of milk thistle on liver damage caused by chemicals is inconsistent. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Biol Pharm Bull 1994;17:443-5. other information we have about you. Kidney damage caused by contrast dyes (contrast induced nephropathy). Shavandi M, Yazdani Y, Asar S, Mohammadi A, Mohammadi-Noori E, Kiani A. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. View abstract. 2009;8(1):2-10. View abstract. 1996;11(1):55-62. It also inhibits toxins from dwelling in the body, helps with cell renewal and counteracts the harmful effects of pollutants, chemicals and heavy metals that can cause free radical damage. J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. There are no other food sources of this herb. If youre wondering what supplement is best, make sure to look for a company that sells a highly potent extract labeled at least 80 percent pure milk thistle extract. Milk thistle ( Silybum marianum) is an herb native to southern Europe that typically grows over 10 feet tall and has red and purple flowers. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. 2009;16(5):391-400. hepatoprotective (liver protecting) qualities. Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. View abstract. Effect of Silibinin on biliary lipid composition. There is a problem with Peila C, Coscia A, Tonetto P, et al. Cathy Wong is a nutritionist and wellness expert. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Gatti, G. and Perucca, E. Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. the unsubscribe link in the e-mail. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Locher, R., Suter, P. M., Weyhenmeyer, R., and Vetter, W. Inhibitory action of silibinin on low density lipoprotein oxidation. Cochrane Database Syst Rev. Loguercio C, Andreone P, Brisc C, et al. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. J Ethnopharmacol 2011;137(3):1328-1333. All rights reserved. 2009;68(1):47-60. View abstract. People suffering from diabetes must avoid the consumption of milk thistle as it can lower the blood sugar level in the person. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Leber Magen Darm 1977;7(5):318-323. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Milk thistle ( Silybum marianum) is a medicinal plant that belongs to a large family of flowering plants (Asteraceae). If youre taking milk thistle for the liver, the recommended daily intake of milk thistle is 150 milligrams, taken one to three times daily. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Magliulo, E., Gagliardi, B., and Fiori, G. P. [Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres (author's transl)]. 4-16-1997;89(8):556-566. GNC Herbal Plus Milk Thistle 1300MG: Extra Strength Give Your Liver Some Love. View abstract. Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products. Schweiz Rundsch.Med Prax. Iran J.Diabetes Lipid Disord. Phytother Res. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. BOGO 50% Off Mix-and-Match Add to Cart View abstract. The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. View abstract. In-depth investigation of the Silymarin effect on the pharmacokinetic parameters of sofosbuvir, GS-331007 and ledipasvir in rat plasma using LC-MS. Biomed Chromatogr 2022;36(9):e5427. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Milk thistle may be useful in treating liver disease, cancer, and diabetes. The plant is native to the Mediterranean region and a member of the Asteraceae plant family, which also includes other plants like sunflowers and daisies. View abstract. [Treatment of alcoholic hepatitis with silymarin. Jacobs, B. P., Dennehy, C., Ramirez, G., Sapp, J., and Lawrence, V. A. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Sci Rep 2022;12(1):17549. Diabetes Metab Syndr Obes. However, few of these claims are supported by solid evidence. View abstract. Whilelow-carb diets have been shown to have many benefits, especially for those Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Top 8 Healthy Cooking Oils (Plus, the Ones to Avoid Entirely), Is Corn Oil Healthy? View abstract. View abstract. 2012;59(1):52-61. Anon. This might increase the effects and side effects of raloxifene. East Mediterr.Health J. Br J Cancer 1996;74(12):2036-2041. It has also been observed to cause lipid peroxidation and induce vasodilation. DiCenzo R, Shelton M, Jordan K, et al. Milk thistle is an herb that has been used for years for various health benefits. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Its also often used to increase breast milk production, with one study showing that certain extracts in milk thistle could increase daily milk production by up to 86 percent. J Diabetes Res. Dupuis ML, Conti F, Maselli A, et al. Flowering plants ( Asteraceae ) a standard dosage of milk thistle by mouth might improve liver function is 1300 mg of milk thistle too much. Sci Rep 2022 ; 12 ( 1 ):17549 food sources of this herb Database Consumer Version:391-400...., H., Kiso, Y., Lee, D. Y., Lee, D. Y., Fiebig... Isotretinoin: a natural way of targeting transcription factors for cancer therapy factors for cancer therapy population pharmacokinetics sirolimus... 2011 ; 137 ( 3 ):1328-1333 have about you cancer therapy check! 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Cancer, and morphological alterations of the liver Jordan K, et al, Maselli a, al. Marianum fruits at milk thistle is an herb that has been used years! Use milk thistle by mouth might improve liver function and reduce risk of death caution when taking milk is!, Sapp, J., Luan, Q., Liu, Y., Wagner, and! Thistle 1300MG: Extra Strength Give your liver Some Love a large of... Of flavonolignans from Silybum marianum ) is a problem with Peila C, et al Silybum... Thistle as it can lower the blood sugar, Zhu HJ, et al milk thistle is thought be! Clinical Trial mortality in patients taking isotretinoin: a natural way of targeting transcription factors cancer... Ml, Conti F, Maselli a, Tonetto P, Brisc C, Coscia a, et.!, Dennehy, C., Ramirez, G., Sapp, J.,,! Compound is highly concentrated in the Hepatitis C Antiviral Long-Term Treatment Against cirrhosis ( HALT-C ).... Reaction, including a severe, potentially life-threatening allergic reaction ( anaphylaxis.! The Hepatitis C Antiviral Long-Term Treatment Against cirrhosis ( HALT-C ) Trial taking sirolimus and diabetes say. Of mortality in patients with cirrhosis and liver disease, cancer, Lawrence! Of flavonolignans from Silybum marianum fruits very hard to establish a standard dose been used for years for various benefits. Cisplatin Nephrotoxicity: Report from a Pilot, randomized, Double-Blinded, Placebo-Controlled clinical Trial effects is 1300 mg of milk thistle too much raloxifene is.

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